Disulfiram is an ancient drug that has been on the market for ages and could represent an important innovation for the tortured Lyme / coinfection patients. According to eminent Lyme practitioners from the USA, long-term remissions appear possible for the first time.
For this article, I’ve heard YouTube interviews for almost a week!
historical background
Disulfiram is a sulfur-containing substance. You immediately see the 4 sulfur atoms with 2 double formations and you see a “reactive” molecule. That is why disulfiram is used in the tire industry for vulcanization – a process in which long-chain rubber molecules (= ropes) are cross-linked by sulfur groups (= nets), which makes the rubber very strong and resistant.
Workers in the rubber factories could no longer tolerate alcohol. This is how the “Antabus” effect was found: those who use Disulfriam as a drug can no longer tolerate alcohol at all and so the drug was used as a prophylaxis against relapse for alcoholics.
Antabus users are less likely to have cancer
it was then found that disulfiram could be used as a cancer drug. Cell culture studies show significant inhibition of breast, prostate and lung cancer, including glioblastoma cells. However, there are hardly any clinical studies.
Disulfiram can produce latent viruses again: HIV
The problem with HIV, for example, is that the latency of the virus prevents it from eroding (eradication). If I could activate latent HIV in a patient, his treatment would be more effective. Disulfiram appears to play a role here.
Spectrum of action
definitely helps in the long term
- Borrelia, also forms of Persis
- Babesia
- less good against bartonelles
- also against viruses, herpes viruses
- Candida, yeast
Antibiotics cannot cure chronic Lyme infections
Antibiotic therapy can reduce the Borrelia by reducing the number of germs and converting it into dormant “persister forms” so that a reasonable life is possible. Nevertheless, relapses are possible for the patients, since the persisters can be reactivated if an immune deficiency situation is triggered (stress, virus infection …).
See the experience of Dr. Uwe auf der Strasse with chronic toxoplasmosis
Taking disulfiram
Ingestion must at least be in a capsule that is insoluble in the stomach, since disulfiram is destroyed by the stomach acid. However, since most of the small intestine disulfiram is broken down in the liver, there is little left to eliminate borrelia, so it would be best to use IV. or i.m. administration or at least 4 hours of delayed-release capsules.
Many of the chronic sufferers have a detoxification weakness, e.g. an MTHFR weakness. This means that they are difficult to handle medication, but also food ingredients. They produce a misleading variety of complaints as side effects of any treatment – no matter what.
Patients with salicylate intolerance are extremely stressful. They even react to almost every food with pain, brain fag, depression, etc. In these patients we see practically an intolerance to disulfiram! We will have to work on decoding this epigenetic induced intolerance. Most people started from living a happy live, just taking some drugs that blocked permanently their ability to deal with salicylic acids that are ubiquitous in nature and food!
Here one has to differentiate the potential disulfiram side effects from the Herxheimer reactions, a flare-up of the neuro-inflammation caused by released bacterial lipopolysaccharides, which is relatively easy.
Dose
The target dose for an approximately 70-80kg patient is between 250-300mg / day.
Under no circumstances should you start therapy with this target dose, it can be the most violent and tw can cause permanent gruesome side effects in the form of neuropathies.
So far, this has only ever happened if high doses -> 500mg Antabus were used, and the medicinal side effects were interpreted as Herxheimer and the patients were encouraged to continue with the agent in this dosage.
For example, we start with our patients with 30mg disulfiram every 3 days after the children’s teacher (with whom I have personal contact) and Liegner and work on Detox weaknesses!
What do the experts add in addition?
everything that improves the Herxheimer reaction: CBD, Curcumin, Boswellia, VitC,….
Scientists & doctors who discovered and used disulfiram
The discoverer is Prof. Rajadas from Standford, the first official user was to my knowledge Dr. Stan Liegner.
The colleague with the most publicity is Dr. Kinderlehrer – the name means “Childrens teacher” in German language and google translated it to that – and he has only 60 patients on disulfiram up to spring 2020.
So there is only a short treasure of experience and only a few experts who work with it.
Dr. Jayakumar Rajadas, scientist in Standford – discoverer of disulfiram against Lyme
Laboratory director at Standford School of Medicine, discovered disulfiram in 2017.
In his laboratory, he examined> 7,500 different medications for their potential effectiveness against Borrelia and published 20 effective ones in 2016.
Disulfiram “sterilizes” the mice – eliminates the infection, at the same time it reduces the neuroinflammation, making it “particularly effective”.
Dr. Rajadas produces models of “neuroinflammation” by injecting colloidal silver into the brain of mice, for example, and then trying to develop therapies.
Disulfiram works best with intraperitoneal injection, so it goes past the liver. Copper is not necessary. So far only tested on Burgdorferi. Metabolites are effective which actually kill the Borrelia.
Minocycline does little for Lyme disease, cannot sterilize, especially Reduce NFkB which means fewer complaints.
Recommends above all Monotherapy – is not a practitioner but a researcher.
PhD Kim Lewis
Dr. Kim Lewis worked extensively on Lyme Disease and scientifically backed up many “guesses”.
- Lyme disease forms persistent forms (which survive any antibiotic therapy) in 2015
- Vancomycin can well eliminate Lyme disease 2018
- Doxycycline and minocycline are the inflammatory reaction against Borrelia from 2009
He has not published Disulfiram himself, but was one of the first to speak to other doctors about it in 2015. Dr. Lewis was one of the first to do Dr. Rajadava made public.
Dr. Kenneth Liegner – first publication
In 2019, Dr. Kenneth Liegner published his first 3 chronic Lyme disease patients. He was made aware of this in 2017 by a patient who was unable to discontinue the antibiotics, otherwise he would immediately have a relapse of his Lyme disease / babesiosis. The patient told him about the work of Dr. Rajadas pointed out and asked him to prescribe Disulfiram
Dr. Dan Kinderlehrer, Dallas
himself affected with Lyme and Bartonellose, very experienced in the treatment of Lyme and coin infections, has been working with disulfiram for 1 year and thinks that this is really a game changer. He has 60 patients with disulfiram so far and does a lot of advertising for it by talking positively about it.
Scott Forsgreen has a great interview podcast.
Psychiatrist Prof. Dr. Robert Bransfield
Dr. Bansfield reports on the high rate of depression and suicide in patients with neurological inflammation of the brain. Dr. Bransfield is a long-time “Lyme doctor” who has treated many seriously ill Lyme disease patients.
Studies
2019 – three cases of chron. Lyme and babesiosis with disulfiram – different drugs were investigated in vitro and disulfiram identified as highly effective. In practice it has been shown that it also eliminates coinfection from Babesia. 500 mg of disulfiram were used
Study 2020 – a case of severe neuropathy due to an overdose of disulfiram. Improved very significantly under immunoglobulin G infusions, then the dose was continued at a low dose of 62.5mg.
Addendum – more information
When I write an article like this, I have the tendency to provide “comprehensive” information, as a scientist to “reference” everything – so that nobody can say “he has sucked it out of his fingers”. I often lose track of things and write far too much about “introduction” or “problem description”. So here too – it was about disulfiram and I made a Lyme disease / coinfection article out of it. Sorry – but it’s a shame about the work, so as an addendum:
Lyme and Co-Infections in the United States
the United States is way ahead of us in the EU. Especially in the vehemence and expansion of chronic invisibility infections with: Borrellia, Mycoplasma (fermentans), Bartonella, Babesia, Chlamydia, parasites, etc., etc.
These germs invad the toxic body and lead to more or less crippling complaints from previously completely healthy people.
Establishment is often helpless towards these patients
Please, please, please watch the TV film of the Australian television team on my page “Neuroborreliosis, how it can look like”. The TV team accompanied seriously ill patients to the St. Georg Bad Aibling clinic for hyperthermia treatment for borreliosis. Then the shocking comments from the Australian health authorities “there is no such thing, they are only mentally ill”.
If you can speak English, we recommend the following film linked below: under your skin
All this is reminiscent of Prof. Ringel’s lectures during my student days: he dragged us fibromyalgia patients into the lecture and told us that each of these pain-stricken patients had been with a total of 35 doctors for 13 years before finally having their diagnosis.
Incidentally, I believe – injected into the tissue due to the good response to low-dose ozone – that fibromyalgia must be an infection with an anaerobic bacterium. Professor Ziad Fahmy, Bad Kreuznach has a clinical study in progress and reports your good results.
- Fahmy, Ziad (Autor)
Why diagnostics is so difficult
“Stealth germs” because these germs are not cleared away by the immune system and spread comfortably in the body to trigger the corresponding symptoms.
- Variety of pains
- Weaknesses
- Brain-fag, concentration disorders, depression, other neurological complaints
- Paralysis
Problem diagnosis and therapy
because the patients in the “normal system” get no help (“they just have to put up with it”), they migrate via Facebook-affected groups etc. to various “experts”.
The following interview with an “MS patient” shows very well how it works today
e.g. BCA – Augsburg (antibiotics), St. Georg Klinik Bad Aibling (high-temperature hyperthermia + antibiotics)
important film: “under your skin”, Documentation about Lyme disease and negating the medical system about the chronic effects of this condition
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